New Platform Focuses on Master Regulators of Skin Longevity to Drive Discovery Across Ingredients, Technologies, Formulations and Future Product Innovation

At the China International Import Expo (CIIE), The Estée Lauder Companies Inc. (NYSE: EL) today unveiled Mastering Skin Longevity, a breakthrough scientific innovation platform designed to advance the next era of skin science and transformative product innovation.

Moving beyond the study of individual Hallmarks of Aging, the platform focuses further upstream on the Master Regulators of Skin Longevity. These interconnected biological pathways and proteins influence multiple hallmarks at once. By deepening understanding of these systems and how they help support skin’s ability to repair, adapt and regenerate, Mastering Skin Longevity will guide the Company’s discovery across ingredients, technologies, formulations and future product innovation.

“Mastering Skin Longevity reflects how we are advancing the next era of skin science and innovation across our brand portfolio,” said Stéphane de La Faverie, President and Chief Executive Officer, The Estée Lauder Companies. “Building on 80 years of scientific leadership and two decades of pioneering longevity research, we are translating breakthrough scientific discoveries into products that consumers trust and love. We are proud to introduce this platform in China, a market at the forefront of scientific and consumer innovation.”

The Company’s authority in skin longevity is grounded in decades of breakthrough scientific research and innovation. For more than two decades, the Estée Lauder brand has pioneered research in areas including sirtuin biology, epigenetics, biological age and cellular repair. This research has powered innovations including Re-Nutriv’s exclusive SIRTIVITY-LP™ technology. Today, scientists across the Company’s Longevity Labs in Melville and Shanghai are advancing research into Master Regulators, including sirtuins, which regulate cellular repair, resilience, and stress response; AMPK, which regulates cellular energy and metabolic adaptation; and mTOR, which regulates cellular renewal, regeneration, and repair signaling.

“The Hallmarks of Aging help us understand what changes in skin over time. The Master Regulators help us investigate the biological systems that influence those changes,” said René Lammers, Executive Vice President and Chief Research & Innovation Officer, The Estée Lauder Companies. “By studying these systems together, we can create a more integrated foundation for discovery and identify new opportunities across ingredients, technologies, formulations and products.”

Mastering Skin Longevity will serve as a shared scientific foundation that brands across The Estée Lauder Companies can apply through their distinct areas of expertise and product philosophies.

Across the portfolio, brands will continue to explore longevity through different areas of focus. These include the Estée Lauder brand’s focus on sirtuin biology and epigenetics; La Mer’s leadership in cellular energy and visible skin renewal; Clinique’s clinically proven approach to helping slow the visible signs of aging and build skin resilience; Lab Series’ focus on optimizing skin performance for men; and The Ordinary’s evidence-based research into age-supporting ingredients and technologies that promote long-term visible skin health.

At CIIE, the Company also introduced the Skin Longevity Clock, an iconic visual representation of the Mastering Skin Longevity platform. Inspired by the precision and interconnected mechanisms of a fine timepiece, the Clock illustrates how the Master Regulators work together to influence multiple Hallmarks of Aging.

The Company also unveiled a comprehensive scientific white paper outlining its perspective on the evolution of skin longevity science and the role of the Master Regulators. The white paper incorporates insights from the Company’s Longevity Scientific Advisory Board, comprising researchers from China, Singapore and the United States, along with The Estée Lauder Companies’ scientists. The Estée Lauder brand also debuted the EstéeLab Longevity Mirror, an immersive experience designed to help consumers understand the factors that influence how skin ages.

For more information about Mastering Skin Longevity, visit ELCompanies.com/MasteringSkinLongevity.

About The Estée Lauder Companies
The Estée Lauder Companies Inc. is one of the world’s leading manufacturers, marketers and sellers of quality skin care, makeup, fragrance and hair care products, and is a steward of luxury and prestige brands globally. The Company’s products are sold in approximately 150 countries and territories under brand names including: Estée Lauder, Aramis, Clinique, Lab Series, Origins, M·A·C, La Mer, Bobbi Brown Cosmetics, Aveda, Jo Malone London, Bumble and bumble, Darphin Paris, TOM FORD, Smashbox, AERIN Beauty, Le Labo, Editions de Parfums Frédéric Malle, GLAMGLOW, KILIAN PARIS, Too Faced, Dr.Jart+, the DECIEM family of brands—including The Ordinary, NIOD, Avestan and Loopha—as well as Balmain Beauty and Forest Essentials.

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The Estée Lauder Companies' Skin Longevity Clock serves as the visual representation for the Mastering Skin Longevity scientific innovation platform.